Substrate: TGF beta R, type II (Dual specificity kinase)
Seq-ID: P37173 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
glycosaminoglycan binding,
transforming growth factor beta receptor activity, type II,
transforming growth factor beta binding,
metal ion binding,
SMAD binding,
type I transforming growth factor beta receptor binding,
ATP binding,
type III transforming growth factor beta receptor binding,
protein binding		 external side of plasma membrane,
caveola,
transforming growth factor beta receptor complex		 pathway-restricted SMAD protein phosphorylation,
positive regulation of mesenchymal cell proliferation,
positive regulation of tolerance induction to self antigen,
patterning of blood vessels,
response to cholesterol,
response to drug,
activation of protein kinase activity,
positive regulation of T cell tolerance induction,
peptidyl-serine phosphorylation,
heart development,
embryonic cranial skeleton morphogenesis,
positive regulation of NK T cell differentiation,
vasculogenesis,
embryonic hemopoiesis,
transforming growth factor beta receptor signaling pathway,
palate development,
peptidyl-threonine phosphorylation,
myeloid dendritic cell differentiation,
positive regulation of B cell tolerance induction,
brain development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 213 TGKTRKLMEFSEHCAIILEDD TGFbR2 9155023
LTP
1.00
 - -
0.18
 - medium
Y 259 LVGKGRFAEVYKAKLKQNTSE TGFbR2 9169454
LTP
0.14
 - STYKc
0.22
 - medium
Y 336 AFHAKGNLQEYLTRHVISWED TGFbR2 9169454
LTP
0.97
 - STYKc
0.14
 - medium
S 409 GLSLRLDPTLSVDDLANSGQV TGFbR2 9155023
LTP
1.00
 - STYKc
0.31
 - medium
S 416 PTLSVDDLANSGQVGTARYMA TGFbR2 9155023
LTP
0.32
 - STYKc
0.37
 - medium
Y 424 ANSGQVGTARYMAPEVLESRM TGFbR2 9169454
LTP
1.00
 - STYKc
0.41
 - medium
S 548 FSELEHLDRLSGRSCSEEKIP - 17081983
HTP
0.23
 - -
0.42
 - medium

Substrate: TGF beta R, type II (Dual specificity kinase)
Seq-ID: Q62312 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-5226700   SHC1_MOUSE
MINT-6544400   TGFR1_MOUSE
MINT-6544409   ACVL1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transforming growth factor beta receptor activity, type II,
metal ion binding,
SMAD binding,
ATP binding		 external side of plasma membrane,
receptor complex,
integral to membrane		 brain development,
mammary gland morphogenesis,
positive regulation of mesenchymal cell proliferation,
protein amino acid phosphorylation,
positive regulation of tolerance induction to self antigen,
patterning of blood vessels,
response to cholesterol,
activation of protein kinase activity,
gastrulation,
lung lobe morphogenesis,
smoothened signaling pathway,
in utero embryonic development,
positive regulation of T cell tolerance induction,
heart development,
embryonic cranial skeleton morphogenesis,
trachea formation,
positive regulation of NK T cell differentiation,
vasculogenesis,
bronchus morphogenesis,
embryonic hemopoiesis,
transforming growth factor beta receptor signaling pathway,
palate development,
myeloid dendritic cell differentiation,
positive regulation of B cell tolerance induction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 250 NCAIILEDDRSDISSTCANNI - 8947046
LTP
1.00
 - -
0.20
 - medium
S 253 IILEDDRSDISSTCANNINHN - 8947046
LTP
1.00
 - -
0.28
 - medium
S 254 ILEDDRSDISSTCANNINHNT - 8947046
LTP
0.35
 - -
0.31
 - medium
S 576 LEHPERLSGRSCSQEKIPEDG - 8947046
LTP
0.19
 - -
0.58
 - medium
S 578 HPERLSGRSCSQEKIPEDGSL - 8947046
LTP
0.32
 - -
0.58
 - medium
S 578 HPERLSGRSCSQEKIPEDGSL - 19144319
HTP
0.32
 - -
0.58
 - medium

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